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Whilst small-depend MBL almost never progresses to CLL, high-count MBL progresses to CLL demanding therapy in a level of 1% to 2% per year. Substantial-count MBL is distinguished from Rai 0 CLL dependant on whether the B-cell count is above or underneath 5 × 109/L. Despite the fact that people today with both equally large-rely MBL and CLL Rai phase 0 are at elevated danger of infections and second cancers, the risk of progression requiring remedy and also the potential LINK ALTERNATIF MBL77 to shorten everyday living expectancy are increased for CLL. This MBL77 evaluation highlights challenging concerns concerning the classification, threat stratification, management, and supportive treatment of sufferers with MBL and CLL.